首頁 ? pGM190 plasmid vector質粒載體 BioVector NTCC質粒載體菌種細胞基因保藏中心

pGM190 plasmid vector質粒載體 BioVector NTCC質粒載體菌種細胞基因保藏中心

  • 價  格:¥49865
  • 貨  號:pGM190 plasmid vector質粒載體
  • 產  地:北京
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pGM190 plasmid vector質粒載體 BioVector NTCC質粒載體菌種細胞基因保藏中心

A team of researchers led by Professor Dr. Yvonne Mast from the Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures in Braunschweig (Germany) have developed a new strategy for the activation of silent antibiotic gene clusters. They showed that the Streptomyces Antibiotic Regulatory Protein (SARP), a regulator that controls the biosynthesis of antibiotics in streptomycetes, can be used as a general activator of various antibiotic gene clusters. The research data on how SARPs can be used to identify and specifically switch on inducible gene clusters have been published in the internationally renowned journal Frontiers in Microbiology.

In their study, the team of Prof. Yvonne Mast was able to show that SARP regulators occur in many different actinomycetes and are part of gene clusters that code for different types of secondary metabolites. In their experiments the researchers showed that SARP regulators have the potential to regulate gene clusters also in other host strains. Using the SARP regulator PapR2 as an example, the researchers demonstrated that this regulator has cluster-activating properties not only in the bacterium Streptomyces pristinaespiralis, in which it occurs naturally; it is also able to activate silent gene clusters in other streptomycetes such as Streptomyces lividans, thereby enabling the production of bioactive substances. By better understanding regulatory mechanisms and with the help of genome sequence data, researchers can now predict which gene clusters can potentially be activated by SARPs, which will facilitate later drug discovery.

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